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Akt2 is a functional target of let-7b and let-7c. (A) Schematic representation of Akt2 3′-UTRs as the putative target of let-7b and let-7c. (B) Western blot analysis demonstrated significant decreased expression of Akt2 in transfected cells. (C) Luciferase assay showed decreased reporter activity after co-transfection of Akt2 3′-UTR plasmid with let-7b or let-7c in 786-O cells (*P < 0.05).
