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. 2015 May 8;13:175. doi: 10.1186/s12957-015-0596-4

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© Peng et al.; licensee BioMed Central. 2015

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Knockdown of Akt2 enhanced the chemosensitivity through caspase-7. (A) Relative cell survival of 786-O cells 48 h after transfected with Akt2 siRNA and treated with 5-FU. Proliferation of 786-O cells after transfection of Akt2 siRNA was significantly reduced compared with negative control (*P < 0.05). (B) Akt2 and caspase-7 protein levels were assessed by Western blot in 786-O cells transfected with si-Akt2 (#1, #2) and negative control. Akt2 knockdown showed the increased expression of caspase-7.