Table 2.
Multivariable log-linear modeling for the association of IL-6 with potential explanatory variables
| Variables | Multivariable model for log10-IL6 level | ||
|---|---|---|---|
| B coefficient | 95% CI | P value | |
| IL-10* | −0.018 | (−0.079, 0.051) | 0.673 |
| TNF-α* | 0.262 | (0.201, 0.391) | < 0.0001 |
| Sex (male) | 0.028 | (−0.040, 0.094) | 0.424 |
| Village (Vuga) | 0.131 | (0.067, 0.240) | 0.001 |
| 5–6 years old | 0.091 | (0.007, 0.269) | 0.040 |
| Wasted† | −0.013 | (−0.113, 0.084) | 0.771 |
| Stunted‡ | 0.021 | (−0.060, 0.102) | 0.609 |
| Malaria | 0.112 | (0.015,0.210) | 0.024 |
| S. haematobium§ | 0.052 | (−0.024,0.129) | 0.180 |
| Hookworm | 0.029 | (−0.070,0.127) | 0.567 |
| Malaria–hookworm | −0.076 | (−0.503, −0.011) | 0.040 |
Final models adjusted for sex, age category, location, wasting, stunting, anemia, individual infections (S. haematobium, malaria, hookworm), and any significant interactions for infection by two or more parasites.
*
log10 of IL-10 and TNF-α.
†
Wasting: Body mass index-for-age Z score (BAZ) < −2 SD.
‡
Stunting: Height-for-age Z score (HAZ) < −2 SD.
§
Positive infection status is defined by S. haematobium egg +/antibody +, egg –/antibody +, or egg +/antibody –.