Table 3.
Multivariable log-linear modeling for the association of IL-10 with potential explanatory variables
| Variables | Multivariable model for log10-IL-10 level | ||
|---|---|---|---|
| B coefficient | 95% CI | P value | |
| TNF-α* | 0.584 | (0.773, 0.947) | < 0.0001 |
| IL-6* | −0.013 | (−0.094, 0.061) | 0.673 |
| Sex (male) | 0.011 | (−0.059, 0.087) | 0.713 |
| Village (Vuga) | 0.123 | (0.092, 0.281) | < 0.0001 |
| 11–12 years | −0.104 | (−0.308, −0.057) | 0.004 |
| 17–19 years old | −0.121 | (−0.468, −0.146) | < 0.0001 |
| Wasted† | 0.107 | (0.001, 0.214) | 0.048 |
| Stunted‡ | −0.035 | (−0.123, 0.054) | 0.434 |
| Malaria | −0.083 | (−0.189, 0.022) | 0.121 |
| S. haematobium§ | 0.207 | (−0.288, −0.126) | < 0.0001 |
| Hookworm | 0.001 | (−0.105, 0.107) | 0.985 |
| Schisto–Filaria | −0.069 | (−0.350, −0.033) | 0.018 |
Final models adjusted for sex, age category, location, wasting, stunting, anemia, individual infections (S. haematobium, malaria, hookworm), and significant interactions for infection by two or more parasites.
*
log10 of IL-6 and TNF-α.
†
Wasting: Body mass index-for-age Z score (BAZ) < −2 SD.
‡
Stunting: Height-for-age Z score (HAZ) < −2 SD.
§
Positive infection status is defined by S. haematobium egg +/antibody +, egg –/antibody +, or egg +/antibody –.