Table 1.
Patients who suffered anaphylactic shock after being treated with 17 types of traditional Chinese medicine injections for cardiovascular and cerebrovascular diseases.
| Serial number | Chinese herbal injections | Constituents | Number of cases | Distributions of ages* | Sex | Mode of delivery | Onset of symptoms | Distributions of onset* | Timely rescue | Number of deaths |
|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Shenmai injection | (1) Red ginseng (2) Ophiopogon japonicus |
39 | 0/22/11/6 | 26 F, 13 M | 36IVI*, 3IMI* | 10 s–1 h | 8/25/6/0/0 | Yes | 0 |
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| 2 | Ciwujia injection | Ciwujia stem and leaf extracts | 33 | 0/11/14/8 | 15 F, 18 M | 33IVI | 3 min–2.5 h | 1/15/13/3/1 | Yes | 0 |
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| 3 | Salvia miltiorrhiza injection | Salvia miltiorrhiza extract | 9 | 0/5/2/2 | 3 F, 6 M | 9IVI | 1 min–30 min | 2/4/3/0/0 | Yes | 0 |
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| 4 | Tanshinone IIA sodium sulfonate injection |
Salvia miltiorrhiza extract; main components: Two terpene quinone compounds | 5 | 0/0/1/4 | 3 F, 2 M | 5IVI | 2 min–30 min | 0/1/4/0/0 | Yes | 0 |
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| 5 | Dan Hong injection | (1) Salvia miltiorrhiza extract (2) Safflower extract |
4 | 0/2/0/2 | 3 F, 1 M | 4IVI | 1 min–40 min | 0/3/1/0/0 | Yes | 0 |
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| 6 | Breviscapine injection | Erigeron breviscapus extract | 11 | 0/2/4/5 | 3 F, 8 M | 11IVI | 3 min–2 h | 0/2/6/3/0 | Yes | 0 |
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| 7 | Erigeron injection |
Erigeron breviscapus extract: phenolic constituents Main component: wild Baicalin, total caffeic acid ester |
6 | 0/0/0/6 | 4 F, 2 M | 6IVI | 10 min–1.5 h | 0/1/4/1/0 | Yes | 0 |
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| 8 | Compound Danshen injection | (1) Salvia miltiorrhiza extract (2) Dalbergia extract |
53 | 0/19/18/16 | 23 F, 30 M | 53IVI | 10 s–2 h | 5/30/15/3/0 | Yes | 5 death, 1 fetal death |
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| 9 | Puerarin injection | (1) Puerarin extract (2) Propylene glycol, water for injection |
23 | 0/1/11/11 | 8 F, 15 M | 23IVI | 2 min–2 h | 1/2/18/2/0 | Yes | 2 |
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| 10 | Safflower injection | Safflower extract Main components: safflower yellow pigment, safflower quinone, glycoside, carthamin, new carthamin |
27 | 0/7/10/11 | 15 F, 12 M | 27IVI | 2 min–1 h | 1/16/10/0/0 | Yes | 0 |
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| 11 | Mailuoning injection | Honeysuckle, Achyranthes root, Dendrobium, Xuan Can | 64 | 1/19/15/29 | 30 F, 34 M | 64IVI | 10 s–50 min | 11/40/13/0/0 | Yes | 2 |
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| 12 | Shengmai injection | Red ginseng, Ophiopogon japonicus, Schisandra chinensis | 16 | 0/2/5/9 | 7 F, 9 M | 16IVI | 10 s–30 min | 3/10/3/0/0 | Yes | 0 |
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| 13 | Shuxuetong injection | Leech and earthworm | 6 | 0/1/3/2 | 4 F, 2 M | 6IVI | 5 min–1.5 h | 0/3/2/1/0 | Yes | 0 |
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| 14 | Xingnaojing injection | Musk, borneol, turmeric, Gardenia | 17 | 2/7/3/5 | 4 F, 13 M | 17IVI | 3 s–45 min | 1/12/4/0/0 | Yes | 0 |
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| 15 | Xuebijing injection | Extracts: safflower, Radix Paeoniae Rubra, Rhizoma Chuanxiong, Radix Salviae miltiorrhizae, Radix Angelicae sinensis Main component: safflor yellow A | 12 | 2/7/2/1 | 7 F, 5 M | 12IVI | 2 min–10 min | 0/12/0/0/0 | Yes | 0 |
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| 16 | Xuesaitong injection | Total saponins of three-seven byproducts, main components: Ginsenoside Rb1, Ginsenoside Rg1, three-seven, Ginsenoside R1 | 21 | 0/3/5/13 | 13 F, 8 M | 20IVI, 1IMI | 2 min–1.5 h | 1/11/8/1/0 | Yes | 0 |
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| 17 | Xueshuantong injection | Three-seven root extracts, main components: Ginsenoside Rg1, Ginsenoside Rb1 | 4 | 0/0/2/2 | 1 F, 3 M | 4IVI | 3 min–1 h | 0/2/2/0/0 | Yes | 0 |
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| Total | 350 | 5/108/106/132 | 169 F, 181 M | 34/189/112/14/1 | ||||||
*Distributions of ages: number of children (≤18 years)/number of youth (19–45 years)/number of middle-aged (46–59 years)/number of aged cases (≥60 years).
*Distributions of onset: within 1 min/between 1 min to 10 mins/between 11 mins to 60 mins/between 61 mins to 120 mins/over 120 mins.
IVI: intravenous injection.
IMI: intramuscular injection.
The references of the cases are in the support material.