Table 6.
Genotype and the allele frequencies of candidate genes in chemotherapy patients.
| Genotype/allele | Responder | Nonresponder | ORa |
95% CI |
P valuea | P value adj.* | |||
|---|---|---|---|---|---|---|---|---|---|
| N | % | N | % | ||||||
| rs2808630 | |||||||||
| T/T | 25 | 71.43 | 64 | 82.05 | 1.000 | ||||
| T/C | 9 | 25.71 | 10 | 12.82 | 0.434 | 0.158 | 1.194 | 0.142 | 0.994 |
| C/C | 1 | 2.86 | 4 | 5.13 | 1.652 | 0.166 | 14.670 | 0.791 | 1 |
| T | 59 | 84.29 | 138 | 88.46 | |||||
| C | 11 | 15.71 | 18 | 13.04 | 0.700 | 0.311 | 1.572 | 0.386 | 1 |
| rs1926203 | |||||||||
| G/G | 23 | 65.71 | 55 | 70.51 | 1.000 | ||||
| G/T | 12 | 34.29 | 17 | 21.79 | 0.592 | 0.245 | 1.435 | 0.244 | 1 |
| T/T | 0 | 0 | 6 | 7.70 | # | # | # | 0.999 | 1 |
| G | 58 | 82.86 | 127 | 81.41 | |||||
| T | 12 | 17.14 | 29 | 18.59 | 1.104 | 0.526 | 2.316 | 0.989 | 1 |
| rs2352028 | |||||||||
| C/C | 22 | 72.86 | 57 | 73.08 | 1.000 | ||||
| C/T | 13 | 37.14 | 21 | 26.92 | 0.623 | 0.267 | 1.457 | 0.221 | 1 |
| T/T | 0 | 0 | 0 | 0 | — | — | — | — | |
| C | 57 | 81.43 | 135 | 86.54 | |||||
| T | 13 | 18.57 | 21 | 13.46 | 0.682 | 0.320 | 1.455 | 0.269 | 1 |
| rs8034191 | |||||||||
| T/T | 34 | 97.14 | 74 | 94.87 | 1.000 | ||||
| T/C | 1 | 2.86 | 4 | 5.13 | 1.838 | 0.198 | 17.068 | 0.477 | 1 |
| C/C | 0 | 0 | 0 | 0 | — | — | — | — | |
| T | 69 | 98.57 | 152 | 97.44 | |||||
| C | 1 | 1.43 | 4 | 2.56 | 1.816 | 0.199 | 16.547 | 0.485 | 1 |
| rs9635542 | |||||||||
| A/A | 10 | 28.57 | 20 | 25.64 | 1.000 | ||||
| G/A | 17 | 48.57 | 37 | 47.44 | 1.088 | 0.420 | 2.819 | 0.866 | 1 |
| G/G | 8 | 22.86 | 21 | 26.92 | 1.312 | 0.431 | 3.996 | 0.809 | 1 |
| A | 38 | 54.29 | 76 | 48.72 | |||||
| G | 32 | 45.71 | 80 | 51.28 | 1.250 | 0.710 | 2.200 | 0.619 | 1 |
| rs4254535 | |||||||||
| T/T | 28 | 80.00 | 46 | 58.97 | 1.000 | ||||
| C/T | 5 | 14.29 | 27 | 34.62 | 3.287 | 1.135 | 9.522 | 0.029 | 0.203 |
| C/C | 2 | 5.71 | 5 | 6.41 | 1.522 | 0.276 | 8.378 | 0.901 | 1 |
| T | 61 | 87.14 | 119 | 76.28 | |||||
| C | 9 | 12.86 | 37 | 23.72 | 2.107 | 0.955 | 4.649 | 0.109 | 0.763 |
| rs1530057 | |||||||||
| C/C | 33 | 94.29 | 71 | 91.03 | 1.000 | ||||
| C/A | 2 | 5.71 | 7 | 95.51 | 1.627 | 0.320 | 8.260 | 0.659 | 1 |
| A/A | 0 | 0 | 0 | 0 | — | — | — | — | |
| C | 68 | 97.14 | 149 | 95.51 | |||||
| A | 2 | 2.86 | 7 | 4.49 | 1.597 | 0.323 | 7.891 | 0.671 | 1 |
P value ≤ 0.05 indicates statistical significance; OR: odds ratio; CI: confidence interval.
aAdjusted by age, gender, smoke status, histology, stage, and chemotherapy regimens.
#When a factor cell associated with the odds ratio is zero, extremely high odds ratios may occur, and it is the same with extremely low odds ratios. It is because the algorithm estimating the logistic coefficient (and hence also exp., the odds ratio) is unstable, failing to converge while attempting to move iteratively toward positive infinity (or negative infinity).
— Some of the mutated genotypes do not exist in the study subjects, so the relative statistics cannot be calculated.
* P value was adjusted by Bonferroni correction.