Table 1. IC50 values of the compounds against tumor cells and normal human cells.
Cytotoxic activity (IC50, μM)a |
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---|---|---|---|---|
Compound | BGC-823b | A549b | HepG2b | HL-7720b |
4-MP-PTOX | 8.72 ± 3.15 | 1.12 ± 0.35 | 1.14 ± 1.07 | 11.30 ± 0.57 |
4-TG-PTOX | 4.40 ± 1.55 | 0.57 ± 0.92 | 0.30 ± 0.34 | 13.51 ± 2.41 |
PTOX | 18.32 ± 2.22 | 20.15 ± 2.75 | 8.36 ± 1.42 | 4.31 ± 1.46 |
Colchicines | 12.17 ± 1.26 | 12.23 ± 0.76 | 13.22 ± 0.88 | 6.42 ± 1.03 |
Nocodazole | 38.89 ± 3.12 | 27.44 ± 2.92 | 18.35 ± 3.71 | 8.51 ± 1.73 |
aStandard deviation (SD) of triplicate samples was calculated from three independent samples, mean ± SD (n = 3)
bMTT methods, drug exposure was for 48 h.