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. 2015 May 7;2(4):e107. doi: 10.1212/NXI.0000000000000107

Figure 3. MAIT cells can be detected within parenchymal lesions of MS brain.

Figure 3

Double fluorescence immunohistochemistry identifies brain-infiltrating mucosal-associated invariant T (MAIT) cells in multiple sclerosis (MS) lesions of patient A. Nuclei are stained with 4',6-diamidino-2-phenylindole (white). Green and red dyes were used. Double-positive cells are therefore shown in yellow. Scale bars 20 µm. (A) T cells expressing the T-cell receptor Vα7.2 (red) and Vβ1 chains (green). This combination (see figure 1B) was identified by single-cell PCR. (B) Most Vα7.2+ (green) T cells belong to the CD8+ (red) T-cell subset. (C) MAIT cells expressing Vα7.2 (red) and CD161 (green) in the parenchyma of MS brain. (D) The vast majority of CD161+ (green) cells in MS CNS coexpress CD8α (red).