Table 1. Clinical characteristics and laboratory data of controls and patients with nonalcoholic fatty liver disease with and without incident diabetes mellitus.
| Control |
NAFLD |
P for trenda | ||
|---|---|---|---|---|
| NAFLD alone | NAFLD with IDM | |||
| n=43 | n=48 | n=42 | ||
| Age, years | 53.0 (48.0–58.0) | 53.5 (49.25–58.75) | 57.0 (52.0–61.0)b | 0.018 |
| Male, n (%) | 21 (48.8) | 27 (56.3) | 22 (52.4) | 0.778 |
| SBP, mm Hg | 118.33±13.35 | 130.52±17.51c | 137.83±20.95d | <0.001 |
| DBP, mm Hg | 77.0 (71.0–82.0) | 84.0 (77.25–89.0)c | 84.0 (79.0–90.0)c | <0.001 |
| BMI, kg/m2 | 23.0 (20.80–24.90) | 25.05 (24.15–27.68)d | 26.71 (24.77–30.58)d | <0.001 |
| AST, U/L | 24 (22–30) | 27 (21–34) | 36.5 (29–52)d, e | <0.001 |
| ALT, U/L | 21 (17–29) | 29 (21.3–42.8)c | 46.5 (35.8–72)d, e | <0.001 |
| Cholesterol, mg/dL | 203.28±37.35 | 208.06±39.54 | 209.50±31.58 | 0.711 |
| Triglyceride, mg/dL | 83.0 (58.0–108.0) | 146.0 (103.25–213.0)d | 159.5 (119.25–213.75)d | <0.001 |
| LDL-C, mg/dL | 129.98±32.03 | 132.53±33.13 | 133.19±30.48 | 0.886 |
| HDL-C, mg/dL | 53.0 (45.0–62.0) | 43.0 (39.25–48.75)d | 41.0 (36.75–47.0)d | <0.001 |
All variables are expressed as n (%) for categorical data and as means ± SD or medians (interquartile ranges) for continuous data with or without a normal distribution, respectively. Abbreviations: ALT, alanine aminotransferase; AST, aspartate aminotransferase; DBP, diastolic blood pressure; HDL-C, high density lipoprotein cholesterol; IDM, incident diabetes mellitus; LDL-C, low density lipoprotein cholesterol; NAFLD, nonalcoholic fatty liver disease; SBP, systolic blood pressure.
aP value by ANOVA or the Kruskal–Wallis test for continuous variables and Pearson Chi-squared test for categorical variables.
bP < 0.05 vs. control.
cP < 0.01 vs. control.
dP < 0.001 vs. control.
eP < .01 vs. NAFLD alone.