Table 2. HWE and observed versus hapmap frequencies.
| Gene SNP (rs#) | Genotype | Observed N (%) | Hapmap N (%) | P value |
|
|---|---|---|---|---|---|
| HWE | Obs-Hap | ||||
| CYP2C8 | A/A | 148 (50.5) | 135 (46.0) | 0.067 | 0.041a |
| g.24879A>Tb | T/A | 111 (37.9) | 137 (46.9) | ||
| (rs11572133) | T/T | 34 (11.6) | 21 (7.1) | ||
| CYP2C9 | G/G | 157 (52.9) | 122 (41.1) | 0.003a | 0.009a |
| g.18470G>Ab | G/A | 103 (34.7) | 138 (46.4) | ||
| (rs4918766) | A/A | 37 (12.5) | 37 (12.5) | ||
| EPHX2 | T/T | 149 (49.3) | 150 (49.6) | 0.666 | 0.031a |
| g.54788T>Cb | C/T | 124 (41.1) | 139 (46) | ||
| (rs2071575) | C/C | 29 (9.6) | 13 (4.4) | ||
| CYP2J2 | T/T | 160 (53.5) | 183 (61.1) | 0.466 | 0.053 |
| g.30354600T>Gb | G/T | 114 (38.1) | 103 (34.5) | ||
| (rs7515289) | G/G | 25 (8.4) | 13 (4.4) | ||
CYP, cytochrome P450; HWE, Hardy–Weinberg Equilibrium; Obs-Hap, observed versus Hapmap frequency comparison; SNP, single-nucleotide polymorphism.
a
Statistical significance established at P<0.05.
b
Tagging SNP.