Table 4. Genetics and long-term outcomes.

Gene SNP (rs#)	Genotype	MRS3 (3–6) N (%)	MRS3 (0–2) N (%)	Unadjusted P value	Adjusteda
					OR (95% CI)	P value
CYP2C9	C/C	39 (62.9)	117 (75)	0.186	Reference	—
g.8633C>Tb	C/T	22 (35.5)	38 (24.4)		2.01 (1.01–3.97)	0.045c
Arg144Cys [c2C]	T/T	1 (1.6)	1 (0.6)		4.46 (0.23–84.97)	0.320
(rs1799853)	T carriers	23 (37.1)	39 (25)	0.074	2.06 (1.05–4.04)	0.036c
EXPH2	DEL/DEL	51 (81)	145 (91.8)	0.021c	Reference	—
g. 50690-50691insGTCb	DEL/GTC	12 (19)	11 (7)		2.81 (1.12–7.05)	0.028c
Thr404del	GTC/GTC	0 (0)	2 (1.3)		—	0.999
(rs71553864)	GTC carriers	12 (19)	13 (8.2)	0.022c	2.55 (1.04–6.24)	0.040c

Gene SNP (rs#)	Genotype	MRS12 (3–6) N (%)	MRS12 (0–2) N (%)	Unadjusted P value	Adjusteda
					OR (95% CI)	P value
CYP2C9	A/A	28 (50.9)	58 (37.9)	0.034c	Reference	—
g.816A>Gd	A/G	17 (30.9)	78 (51)		0.48 (0.23–0.99)	0.048c
(rs2253635)	G/G	10 (18.2)	17 (11.1)		1.15 (0.44–2.97)	0.780
	G carriers	27 (49.1)	95 (62.1)	0.093	0.61 (0.32–1.18)	0.140
CYP2J2	G/G	55 (93.2)	133 (84.7)	0.037c	Reference	—
g.4930G>Tb	G/T	3 (5.1)	24 (15.3)		0.28 (0.08–0.99)	0.048c
c.-76G>T[c7]	T/T	1 (1.7)	0 (0)		—	1.000
(rs890293)	T carriers	4 (6.8)	24 (15.3)	0.115	0.36 (0.12–1.14)	0.082
EXPH2	C/C	51 (86.4)	109 (70.3)	0.047c	Reference	—
g.30221G>Ab	T/C	8 (13.6)	44 (28.4)		0.38 (0.16–0.89)	0.027c
Arg287Gln	T/T	0 (0)	2 (1.3)		—	0.999
(rs751141)	T carriers	8 (13.6)	46 (29.7)	0.015c	0.36 (0.15–0.84)	0.019c

CI, confidence interval; CYP, cytochrome P450; MRS, Modified Rankin Scale score at 3 and 12 months: Unfavorable (3 to 6), Favorable (0 to 2); OR, odds ratio; SNP, single-nucleotide polymorphism.

^aMultivariate analysis included correction for age, sex, and Hunt & Hess Score.

^bFunctional SNP.

^cStatistical significance established at P<0.05.

^dTagging SNP.