Figure 2.
Long-term adverse outcome of neonatal seizures on endothelium- and astrocyte-dependent components of the cerebral blood flow regulation. Postictal cerebral vascular responses to topical endothelium-dependent dilator bradykinin (BK, 10−6 mol/L), astrocyte-dependent dilator ADP (10−4 mol/L), endothelium/astrocyte-dependent dilators glutamate (Glu, 10−4 mol/L), quisqualic acid (Quis, 10−4 mol/L), heme (10−5 mol/L), and vascular smooth muscle-dependent dilator sodium nitroprusside (SNP, 10−6 mol/L) were tested in newborn piglets 48 hours after the seizure. Postictal cerebral vascular function is expressed as the percent reduction of the intact control cerebral vascular responses. N=6 animals, n=30 arterioles in each group. *P<0.05 compared with intact control values.