Skip to main content
. 2014 Nov 5;35(2):193–199. doi: 10.1038/jcbfm.2014.196

Figure 4.

Figure 4

Enteral supplements of CORM-A1 improve postictal cerebral vascular responses to endothelium-dependent dilator bradykinin and astrocyte-dependent dilator ADP. Cerebral vascular responses to topical bradykinin (10−6 mol/L) and ADP 10−4 mol/L were tested 48 hours after seizures in: seizures saline control piglets (Ctr Group II); piglets treated with enteral CORM-A1 (2 mg/kg) administered 10 minutes before (CORM-A1 Group III) or 20 minutes after bicuculline (CORM-A1 Group IV); inactivated CORM-A1 (CORM-A1 Group V); and piglets treated with bilirubin administered 20 minutes after bicuculline (5 mg/kg intravenously, BR Group VI). Control responses to the vasodilators were tested in no-seizure intact control group (Group I). Postictal cerebral vascular function is expressed as % of control responses in no-seizure intact control group (Group I). N=4 animals, n=25 arterioles in each group. *P<0.05 compared with the intact control. †P<0.05 compared with the seizure saline control.