Figure 7.

Bias in pseudo reference tissue model (PRTM) estimates of binding potential for different model topologies. The solid line in each plots represent the biased simplified reference tissue model (SRTM) estimate of binding potential because of the uncorrected presence of specific binding in the reference region. The dashed line is the bias for PRTM. When one tissue compartment (1TC) is present in both reference and target regions, PRTM is able to provide an unbiased estimate of binding potential, but for more complex model configurations a bias (either positive or negative) is nearly always present.