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. 2014 Sep 16;23(1):171–178. doi: 10.1038/mt.2014.156

Figure 6.

Figure 6

Antigen-dependent expansion of EphA2-ENG T cells and bystander T cells in vivo. (a) A549 tumor- or nontumor-bearing mice received an intravenous (i.v.) injection of an admixture of 5 × 106 eGFP.ffLuc-expressing EphA2-ENG and 5 × 106 NT T cells, and one intraperitoneal (i.p.) dose of IL-2 (1,500 units). Serial bioluminescence imaging was performed to track T cells (means ± SD are shown; n = 5 per group; *P < 0.05, **P < 0.01, ***P < 0.005). (b) A549 tumor-bearing mice received an i.v. injection of an admixture of 5 × 106 EphA2-ENG and eGFP.ffLuc-expressing 5 × 106 NT cells or 5 × 106 CD19-ENG and eGFP.ffLuc-expressing 5 × 106 NT cells, and one i.p. dose of IL-2 (1,500 units). Serial bioluminescence imaging was performed to track T cells (means ± SD are shown; n = 5 per group; *P < 0.05, ***P < 0.005).