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. 2014 Oct 7;23(1):71–78. doi: 10.1038/mt.2014.176

Figure 3.

Figure 3

miR-1280 suppresses Src and inhibits A375 melanoma cell proliferation, colony formation, and invasion, and induces apoptosis. (a) Relative miR-1280 expression levels in A375 cells following transfection with miR-1280 as determined by miR qRT-PCR. (b) Western blot analysis showing miR-1280-mediated effect on Src expression and its downstream targets. (c) The proliferative ability of A375 cells after miR-1280 transfection (d) miR-1280 overexpression significantly inhibits the colony formation ability of A375 melanoma cells. (e) Cell cycle analysis of A375 cells after transfection of miR-1280. (f) Apoptotic index of A375 cells after miR-1280 overexpression when compared with cont.miR-expressing cells. (g) miR-1280 overexpression significantly suppressed the invasive ability of A375 melanoma cell lines. (c–g) Data presented reflect mean ± SEM of three independent experiments. *P < 0.05.