Figure 4.

EGFR-retargeted miR-124-sensitive HSV vector treatment of a nude mouse model of human glioblastoma. Triturated GBM30 cells were implanted intracranially and 5 days later, PBS or 1.8 × 10⁸ gc of KGE or KGE-4:T124 virus were injected at the same coordinates. (a) Kaplan–Meier survival plot. Log-rank statistics: KGE versus PBS, P = 0.0188; KGE-4:T124 versus PBS, P = 0.0009; KGE versus KGE-4:T124, P = 0.8327. (b) Animal weights over time post tumor-cell implantation. X, animal death or euthanasia.