Figure 2.

Tumor selective infection, systemic spread, and clinical activity of vvDD in patients. (a) Evolution of response in patient #5 with breast cancer metastatic to the skin. vvDD replication leads to an ulcerated region encompassing only the tumor, which is resolving and scabbed over by day 28. (b) Another example of antitumor activity in patient #3 with breast cancer metastases to skin. A noninjected lesion 12 cm from the injected lesion became pustular and virus was recovered by plaque assay(*) on day 8. A similar lesion became pustular and resolved by day 28. (c) Patient #16 with metastatic colon cancer to the subcutaneous tissue and skin demonstrates significant erythema on day 8 at the two injected sites, consistent with active vvDD replication, and vvDD was recovered from the biopsy by plaque assay(*). A noninjected cutaneous lesion on the shoulder also became pustular and vvDD was recovered(*) on day 8. (D) In patient # 8, an omental mass of metastatic colon cancer was injected and a CT scan at day 30 revealed a markedly necrotic tumor and surrounding inflammation.