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Immunologic effects of vvDD. (a) By phosflow analysis, pERK, pS6, and Ki67 were upregulated in circulating CD4 and CD8 T cells after vvDD injection in a dose-dependent manner. (b) Comparison of injected and noninjected tumor biopsies in compassionate use patient with melanoma on day 8 by qPCR for inflammatory markers. All proinflammatory markers are upregulated in the injected tumor, but the anti-inflammatory marker CCL22 is unchanged.
