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. Author manuscript; available in PMC: 2015 May 11.
Published in final edited form as: Mol Imaging. 2011 Dec;10(6):420–433.

Figure 1.

Figure 1

Characterization of SW120. A, Flow cytometric determination of the internalization of SW120 in MDAMB-435 cells with and without blocking by SW43 (solid triangles), sirame-sine (solid diamonds), or (+)-pentazocine (open circles). B, Kinetics for the internalization of SW120 in MDA-MB-435 cells. C, Kinetics for the internalization of SW116 in MDAMB-435 cells. D, Kinetics for the efflux of SW120 in MDA-MB-435 cells. E, Kinetics for the efflux of SW116 in MDA-MB-435 cells. F, The inhibition of SW120 internalization by phenyl-arsine oxide (PAO). MDA-MB-435 cells were preincubated with or without 10 μM PAO for 30 minutes at 37°C and then incubated with 10 nM SW120 for an additional 15 and 30 minutes. The cells were analyzed by flow cytometry. The internalization of SW120 was significantly reduced by 10 μM PAO (*p < .005).