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. Author manuscript; available in PMC: 2015 May 11.
Published in final edited form as: Int Rev Cell Mol Biol. 2011;287:191–231. doi: 10.1016/B978-0-12-386043-9.00005-0

Figure 5.5. Vinculin is required for proper cell–cell adhesion.

Figure 5.5

In the presence of vinculin (left panel), E-cadherin is stably expressed at the cell surface and strong adhesions are formed between neighboring cells. Upon the loss of vinculin (right panel), cell–cell adhesions disassemble, and E-cadherin is lost from the cell surface and is internalized.