Table 4.

Deferred Late Effects/Quality of Life Trials

Domain	Rationale for Deferral
Preventive care	Smoking cessation – no preliminary data Vaccinations – could only be in a limited number of centers and may not need the Network Vitamin D supplementation – appropriate endpoints unclear
Survivor support	Survivorship care plan – ongoing funded multicenter study Internet-based survivorship support – ongoing funded multicenter study (INSPIRE) Survivorship support package – would require extensive development
QOL, economics Late effects	Usually appropriate as secondary endpoints Cardiotoxicity – need very late follow-up, expensive study, rare outcome Sexual dysfunction – lack of preliminary data Iron overload – unclear clinical implications, premature for an intervention study Infertility – lack of a feasible intervention Avascular necrosis – lack of a feasible intervention