Table 1.
The expression of genes associated with autophagy in thyroids obtained from 4W and 8M rats 24 h after irradiation was analyzed using pathway-specific PCR array. Fold change represents the average of triplicate experiments from single rats. The bold numbers indicate a more than 2-fold increase. *P < 0.05 compared with non-irradiated group, unpaired Student t test.
| Gene symbol | Gene name | Fold change |
|
|---|---|---|---|
| 4W rat | 8M rat | ||
| Atg12 | Autophagy-related 12 homolog (S. cerevisiae) | 1.5 | 0.57* |
| Atg16l1 | Autophagy-related 16-like 1 (S. cerevisiae) | 1.58 | 0.95 |
| Atg16l2 | Autophagy-related 16 like 2 (S.cerevisiae) | 3.32* | 0.96 |
| Arg5 | Autophagy related 5 homolog (S. cerevisiae) | 1.43 | 0.87 |
| Atg9a | Autophagy-related 9A (yeast) | 2.08 | 1.39 |
| Bax | Bcl-associated X protein | 3.09* | 1.38 |
| Bcl-2 | B-cell CLL/lympnoma 2 | 1.2 | 0.72* |
| Casp3 | Caspase 3 | 1.69 | 1.67* |
| Ctss | Cathepsin S | 3.25* | 1.94* |
| Dapk1 | Death associated protein kinase 1 | 2.32 | 2.09 |
| Fas | Fas (TNF receptor superfamily, member 6) | 6.06* | 6.35* |
| Irgm | Immunity-related GTPase family M | 2.46* | 0.92 |
| Map1lc3a | Microtubule-associated protein 1 light chain 3 alpha | 1.82 | 1.04 |
| Mapk14 | Mitogen-activated protein kinase 14 | 1.16 | 0.72* |
| Mapt | Microtubule-associated protein tau | 1.86* | 0.56* |
| Pink1 | PTEN induced putative kinase 1 | 2.06 | 2.52* |
| Sqstm1 | Sequestosome 1 | 1.19 | 0.77 |
| Tnfsf10 | Tumor necrosis factor (ligand) superfamily, member10 | 1.99* | 1.23 |
| Wipi1 | WD repeat domain, phosphoinositide interacting 1 | 1.95 | 1.61* |