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. 2015 Mar;6(3-4):169–181. doi: 10.18632/genesandcancer.54

Figure 4. HDAC1/2 knockdown by siRNA significantly reverses cisplatin resistance and tumorsphere formation.

Figure 4

HDAC1 and HDAC2 were knocked down in CAL27-CisR and UD-SCC-2-CisR cells by siRNA. A-B: HDAC1 and HDAC2 knockdown was verified by Western blotting. Survivin and nanog expression was examined in HDAC1&2 knockdown cells. C: HDAC1&2 were knocked down in CAL27-CisR cells and cell proliferation examined by MTT. D-E: Tumorsphere formation efficiency was examined in CAL27-CisR and UD-SCC-2-CisR cells after knocking down HDAC1&2. *, represent a significant higher tumorsphere numbers as compared to control.