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. Author manuscript; available in PMC: 2016 May 20.
Published in final edited form as: Tetrahedron Lett. 2015 May 20;56(21):2832–2835. doi: 10.1016/j.tetlet.2015.04.061

Scheme 2.

Scheme 2

Synthesis of pyrazolone derivatives. Reagents and conditions: (a) SOCl2, DMF, 90 °C, 3 h; (b) MeOAc, LDA, THF, −78 °C then rt, 1 h; (c) 1,5-diiodopentane, K2CO3, DMF, 90 °C, overnight; (d) hydrazine hydrochloride, acetic acid, 120 °C, 2 h; (e) hydrazine hydrochloride, DIPEA, BuOH, 120 °C, 3 h; (f) alkyl bromide, K2CO3, DMF, 70 °C, 2 h; (g) NaH, alkyl bromide, DMF, 60 °C, 3 h.