Table 1.
| |||
---|---|---|---|
Cpd | R | R1 | TbrPDEB1 (% inh)a |
10a | OCH2CH3 | CH3 | 8 ± 11 |
10b | OH | CH3 | 17 ± 9 |
11a | CH3 | 5 ± 5c | |
11b | CH3 | 7 ± 5c | |
11c | CH3 | 8 ± 0 | |
11d | CH3 | 6 ± 6 | |
11e | CH3 | 16 ± 11 | |
11f | CH3 | 10 ± 5 | |
11g | CH3 | 16 ± 6 | |
11h | NHCH3 | CH3 | 8 ± 0 |
11i | NHCH2CH3 | CH3 | 5 ± 4 |
11j | CH3 | 1 ± 2 | |
11k | CH3 | 10 ± 3 | |
13a | OCH2CH3 | SO2CH3 | 3 ± 4 |
13b | OCH2CH3 | COCH3 | 15 ± 0 |
Data shown are average of 2 replicate independent experiments. Compounds were tested at 10 µM concentrations.
n=1
Replicate of 3 independent experiments.