Table 1.

rac-(trans-3,4)-Disubstituted pyrrolidine analogs tested against TbrPDEB1

Cpd	R	R1	TbrPDEB1 (% inh)a
10a	OCH2CH3	CH3	8 ± 11
10b	OH	CH3	17 ± 9
11a		CH3	5 ± 5c
11b		CH3	7 ± 5c
11c		CH3	8 ± 0
11d		CH3	6 ± 6
11e		CH3	16 ± 11
11f		CH3	10 ± 5
11g		CH3	16 ± 6
11h	NHCH3	CH3	8 ± 0
11i	NHCH2CH3	CH3	5 ± 4
11j		CH3	1 ± 2
11k		CH3	10 ± 3
13a	OCH2CH3	SO2CH3	3 ± 4
13b	OCH2CH3	COCH3	15 ± 0

^aData shown are average of 2 replicate independent experiments. Compounds were tested at 10 µM concentrations.

^bn=1

^cReplicate of 3 independent experiments.