Skip to main content
. Author manuscript; available in PMC: 2016 May 20.
Published in final edited form as: Tetrahedron Lett. 2015 May 20;56(21):2832–2835. doi: 10.1016/j.tetlet.2015.04.061

Table 3.

Spiro pyrazolone analogs tested against TbrPDEB1

graphic file with name nihms685683t15.jpg
Cpd R R1 TbrPDEB1 (% inh)a
21a graphic file with name nihms685683t16.jpg H 11 ± 10
21b graphic file with name nihms685683t17.jpg graphic file with name nihms685683t18.jpg 18 ± 2
21c graphic file with name nihms685683t19.jpg graphic file with name nihms685683t20.jpg 9 ± 4b
21d graphic file with name nihms685683t21.jpg graphic file with name nihms685683t22.jpg 9 ± 6b
22a graphic file with name nihms685683t23.jpg H 14 ± 20
22b graphic file with name nihms685683t24.jpg graphic file with name nihms685683t25.jpg 11 ±10b
22c graphic file with name nihms685683t26.jpg graphic file with name nihms685683t27.jpg 7 ± 5
22d graphic file with name nihms685683t28.jpg graphic file with name nihms685683t29.jpg 10 ± 3
a

Data shown are average of 2 replicate independent experiments. Compounds were tested at 10 µM concentrations.

b

Replicate of 3 independent experiments.