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. 2015 Apr 27;2015:595273. doi: 10.1155/2015/595273

Figure 3.

Figure 3

Protein production assays for MMP-1 and PGE2 in vitro after treatment with TNF-α with or without additional drugs. MMP-1 and PGE2 after treatment with TNF-α (5 ng/mL) with or without drug treatment. (a) shows that TNF-α induced MMP-1 production (compare columns 1 and 2). All drug/TNF-α combinations result in less MMP-1 production, with celecoxib reducing production of MMP-1 most dramatically. (b) shows that TNF-α alone induces PGE2 production. All drugs significantly reduce PGE-2 production, celecoxib being the most effective. The dotted line represents PGE-2 production with no TNF-α and no drug treatment.