Table 3.

Clinical descriptions and evaluations of the three patients who were diagnosed with disorders that would pre-dispose to bleeding symptoms.

Diagnosis	Clinical presentation	Evaluation	Additional comments
Late Vitamin K deficiency	Previously well 3-month-old male who presented with jaundice, new seizure activity and intracranial hemorrhage.	Initial: PT > 100 s, aPTT 184.5 s Follow-up: PT & aPTT improved with plasma transfusion. No factor activities obtained.	The baby was ultimately diagnosed with cholestatic liver disease, which resulted in vitamin K, A and D deficiency, as well as failure to thrive.
Hemophilia A	Previously well 5-month-old male who presented with enlarging hip bruise and prior history of cephalohematoma.	Initial: PT 13.3 s, aPTT 116.9 s Follow-up: factor VIII <1%, factor IX 66%, factor XII 39%	Repeat testing demonstrated persistence of factor VIII activity reduction. Hematology consult obtained due to isolated laboratory abnormality.
Osteogenesis Imperfecta	6 month old with previously diagnosed Osteogenesis Imperfecta (COL1A1 mutation) presented with bilateral frontal subdural hemorrhages, acute and subacute, without skull fracture after a witnessed fall.	Ophthalmology evaluation for retinal hemorrhages: negative. Skeletal survey: negative. Hematologic laboratory evaluation: normal.