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. Author manuscript; available in PMC: 2015 May 11.
Published in final edited form as: J Am Chem Soc. 2012 Dec 3;134(49):20070–20080. doi: 10.1021/ja305636u

Figure 5.

Figure 5

tTER mutants that disrupt base pairing in the pseudoknot prevent reconstitution of robust telomerase activity. Telomerase activity of the tTERT-tTER minimal complex was determined by direct primer extension. LC indicates a loading control used form normalization.