TABLE II.

Total Prevalence of Phocomelia in 19 Surveillance Programs of the International Clearinghouse for Birth Defects Surveillance and Research

Surveillance program	Period	Births	Total number of cases	% Of total cases that were SB	% Of total cases that were ETOPFAa	Total prevalence per 100,000 births	95% CI
Canada Alberta	1980–2005	1,062,483	5	0	16.7	0.47	0.15–1.10
USA Utah	1997–2004	380,706	1	0	0	0.26	0.01–1.46
USA Atlanta	1968–2004	1,283,999	11	27.3	9.1	0.86	0.43–1.53
USA Texas	1996–2002	2,054,788	12	8.3	0	0.58	0.30–1.02
Mexico RYVEMCE	1978–2005	1,058,885	9	11.1	NP	0.85	0.39–1.61
South America ECLAMC	1982–2006	4,556,173	7	28.6	NP	0.15	0.06–0.32
Finland	1993–2004	713,494	2	0	100	0.28	0.03–1.01
Germany Saxony—Anhalt	1980–2004	355,184	4	0	50.0	1.13	0.31–2.88
Slovak Republic	2000–2005	318,257	4	0	0	1.26	0.34–3.22
France Central East	1979–2004	2,500,214	19	10.5	44.8	0.76	0.46–1.19
Italy North East	1981–2004	1,186,497	2	0	0	0.17	0.02–0.61
Italy Emilia Romagna	1982–2004	558,176	7	0	0	1.25	0.50–2.58
Italy Tuscany	1992–2004	336,744	3	0	100	0.89	0.18–2.60
Italy Campania	1992–2004	643,962	8	0	12.5	1.24	0.54–2.45
Italy Sicily	1991–2002	216,257	3	0	0	1.39	0.29–4.05
Spain ECEMC	1980–2004	2,045,751	12	25.0	NR	0.59	0.30–1.02
Israel	1975–2005	151,562	1	0	0	0.66	0.02–3.68
China Beijing	1992–2005	1,927,622	11	72.7	NR	0.57	0.28–1.02
Australia Victoria	1983–2004	1,390,179	20	35.0	10.0	1.44	0.88–2.22
Total		22,740,933	141	19.1	14.9a	0.62	0.52–0.73

ECEMC, Estudio Colaborativo Español de Malformaciones Congénitas; ECLAMC, Estudio Colaborativo Latino-Americano de Malformaciones Congénitas; RYVEMCE, Registro y Vigilancia Epidemiológica de Malformaciones Congénitas; SB, Stillbirths; ETOPFA, elective termination of pregnancy for foetal anomaly; CI, confidence interval; NP, not permitted; NR, not reported.

^aThe percentage computed on the 15 surveillance programs registering ETOPFA is 20.6% (n=21/102).