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. 2015 Apr 27;2015:459052. doi: 10.1155/2015/459052

Figure 1.

Figure 1

Coadministration of carfilzomib and LBH589 induced a synergistic inhibition of proliferation in MM cells. (a) All cell lines were incubated for 48 h with carfilzomib and/or LBH589 (low: 2 nM LBH589, 20 nM carfilzomib; intermediate: 4 nM LBH589, 40 nM carfilzomib; and high: 6 nM LBH589, 60 nM carfilzomib) followed by CCK-8 assay. Data represent the mean ± SD for three separate experiments performed in triplicate. ∗ P < 0.05. ∗∗ P < 0.01. ∗∗∗ P < 0.001. # P > 0.05. CFZ, carfilzomib. (b) CI values were calculated using median dose effect analysis. CI values < 1.0 denote synergistic interactions.