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. 2015 May 11;10(5):e0126875. doi: 10.1371/journal.pone.0126875

Fig 2. Cyclin B1 high expression negatively correlates with poor survival of colorectal cancer patients.

Fig 2

(A) The optimal cut-off level of Cyclin B1 relative expression was determined based on the largest of sensitivity and specificity by receiver operating characteristic curve (ROC) analysis for overall survival. Area under curve (AUC) of ROC was 0.90. (B) According to the optimal cut-off value (3.33-fold), 150 patients with colorectal cancer were divided into two groups: ≥ 3.33 were considered as an elevated Cyclin B1 expression group (n = 88); < 3.33 were considered as a low Cyclin B1 expression group (n = 62). (C) Kaplan-Meier survival analysis according to Cyclin B1 expression in patients with colorectal cancer (log-rank test). (D) Cumulative overall survival curves of patients with high or low Cyclin B1 expression levels by multivariate analysis.