Table 1.
Baseline clinical characteristics
| Clinical characteristics | At baseline | After 18 months of PD | p value |
|---|---|---|---|
| Age, years | 60.5 (26–76) | ||
| Men | 25 (50) | ||
| Smoker | 18 (45) | ||
| Body mass index | 25.9 ± 3.7 | 25.7 ±2.2 | n.s. |
| Diabetes mellitus | 26 (52) | ||
| Mean arterial pressure, mm Hg | 109.2 ± 15.1 | 95.4 ±8.2 | <0.001 |
| Cause of ESRD | |||
| Diabetic nephropathy | 24 (48) | ||
| Hypertensive nephrosclerosis | 9 (18) | ||
| Glomerulonephritis | 7 (14) | ||
| Pyelonephritis | 7 (14) | ||
| Other | 3 (6) | ||
| Antihypertensives, n | |||
| On ARB or ACE inhibitor | 32 | 24 | |
| On diuretic | 36 | 18 | |
| On calcium channel blocker | 21 | 29 | |
| Other | 9 | 3 | |
| Laboratory measurements | |||
| Hemoglobin, g/l | 101.9 ± 10.3 | 118.6 ±11.1 | <0.001 |
| Albumin, g/l | 30.9 ± 2.6 | 31.5 ±2.0 | <0.01 |
| Urea nitrogen, mmol/l | 25.7 ± 6.7 | 17.5 ±2.5 | <0.001 |
| Creatinine, μmol/l | 912.3 ± 223.3 | 733.9 ±131.0 | <0.001 |
| Cholesterol, mmol/l | 6.5 ± 1.6 | 5.5 ±1.3 | <0.001 |
| Triglyceride, mmol/l | 2.4 ± 1.3 | 2.0 ±2.5 | <0.01 |
| Low-density lipoprotein, mmol/l | 4.7 ± 1.4 | 3.6 ±0.8 | <0.05 |
| C-reactive protein, mg/l | 11.1 (6.1–16.4) | 4.5 (2.8–7.7) | <0.001 |
| Fibrinogen, g/l | 6.2 ± 1.9 | 4.4 ±1.3 | <0.001 |
| Calcium, mmol/l | 2.2 ± 0.2 | 2.3 ±0.1 | n.s. |
| Phosphorous, mmol/l | 1.8 ± 0.3 | 1.6 ±0.2 | <0.05 |
| CaxP | 3.9 ± 0.6 | 3.6 ±0.5 | <0.001 |
| ß2-Microglobulin | 7.0 (2.9–11.2) | 4.2 (2.3–9.7) | <0.05 |
| Parathyroid hormone, pmol/l | 225.5 (97.8–387) | 200.0 (100.0–410) | n.s. |
| Plasma homocysteine, µmol/l | 25.2 (20.2–30.1) | 18.0 (14.0–20.9) | <0.001 |
| B-type natriuretic peptide, pg/ml | 183.9 (89.8–432.5) | 69.6 (50.2–98.8) | <0.001 |
| Troponine, ng/ml | 0.022 (0.001–0.12) | 0.001 (0.00–0.01) | <0.01 |
| Nitric oxide, μmol/l | 40.72 (19.4–56.7) | 48.0 (32.8–60.4) | <0.01 |
| ET-1, pg/ml | 6.32 (3.2–8.8) | 4.0 (2.27–6.3) | <0.001 |
| RRF, ml/min/1.73 m2 | 5.5 ± 3.8 | 7.0 ±5.0 | <0.05 |
| Urine volume, ml/day | 545.6 ± 378.5 | 584.8 ±489.7 | n.s. |
| nPNA, g/kg/day | 0.98 ± 0.13 | 1.11 ±0.1 | <0.05 |
| Weekly Kt/Vurea | 1.9 ± 0.8* | 2.1 ±0.6 | <0.05 |
Data are expressed as the mean ± SD, number (percentage) or median (range). n.s. = Not significant; ARB = angiotensin receptor blocker; ACE = angiotensin-converting enzyme; nPNA = protein equivalent of total nitrogen appearance.
a
After 6 months of PD.