Fig 1. Workflow of model selection strategy.

Quantitative time resolved data is discretized for the selection of submodels of the interaction graph master model. The interaction graph master model is based on literature knowledge and consists of the “core model” and reported interactions between the signaling pathways of interest, the “candidate mechanisms”. Ordinary differential equation (ODE) modeling utilizes the entire information of the time resolved data. Model selection based on parameter estimation permits the selection of the best model structure.