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. 2015 May 11;10(5):e0126607. doi: 10.1371/journal.pone.0126607

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© 2015 Huan et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Fig 4 — A, cloned piglets without or with macroglossia, B and C, methylation statuses of H19/Igf2 in cloned piglets. IVF, the IVF piglets, NT-CON-N, normal cloned piglets in the NT-CON group, NT-CON-M, cloned piglets with macroglossia in the NT-CON group, and NT-TSA-N, normal cloned piglets in the NT-TSA group. TSA prevented the disrupted imprinting of H19/Igf2 and macroglossia occurrence of cloned piglets. Black or white circles indicate methylated or unmethylated CpG sites, respectively. The data were expressed as mean ± SEM. ^a-bValues with different superscripts differ significantly (P<0.05).