Fig 4. Summary results of whole exome sequencing for all matched samples (n = 12).

Top panel, details of mutations found in tumors in each specific samples (blue squares are single-nucleotide variants (SNVs) and red squares are insertions and deletions (Indels). Right panel shows the mutations per exome, the amount of mutations in driving and DNA repair genes and total number of mutations per tumor. Lower panel shows gene annotations derived from present results and other studies: Recurrent gene mutated in more than one sample in present series; Mutated in triple negative breast cancer (TNBC) [7], significantly mutated in TNBC from TCGA [49,50]; Oncogenes and tumor suppressors class derived from references [21,51]; Epigenetic modifiers class derived from references [52,53]; Clinical target, genes that are targets of drugs in clinical trials or approved by FDA. (http://www.fda.gov/Drugs/InformationOnDrugs/ApprovedDrugs/default.htm).