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. 2015 May 7;145(2):279–287. doi: 10.1111/imm.12446

Figure 4.

Figure 4

12-O-Tetradecanoylphorbol 13-acetate (TPA) -treated progranulin-deficient (PGRN−/−) mice have decreased percentages of regulatory T (Treg) cells in the affected skin and cervical lymph nodes. (a) Percentages of T helper type 1 (Th1), Th2, Th17 and Treg cells in the ears and cervical lymph nodes in WT and PGRN−/− mice on day 9 after application of TPA to the ears on days 0, 2, 4, 6 and 8 measured by flow cytometry are shown as means ± SEM of four mice/group (***P < 0·001; **P < 0·005). (b) Representative dot plots for Treg cells in the ears and cervical lymph nodes in WT and PGRN−/− mice are shown; numbers beside boxes indicate the percentages of Treg cells among CD4+ T cells.