Table 1. Candidates of malignant transformation suppressors identified from an shRNA based genetic screen in BEAS-2B cells.

Target gene symbol	Description	Validation
INPP4B *	Inositol polyphosphate 4- phosphatase	Yes
Sesn2 *	Homo sapiens sestrin 2	Yes
TIAR**	T-cell intracellular antigen 1-related protein	Yes
ACRC**	Acidic repeat containing	N/A
NUP210 **	Nucleoporin 210kDa	N/A
LMTK3 **	Lemur tyrosine kinase 3	N/A

* An identical shRNA against INPP4B or Sesn2 transcript was identified three times

from three independent transformed colonies.

** These unique shRNAs were identified only one time from only one transformed colony