Table 2. Morphological Measures of Bone Marrow Recovery in ALL.
| At Dx | Day 15 | Day 29/Day 33 | Type III effect of time. P | |
|---|---|---|---|---|
| N o of samples | 44 | 26 | 30 | |
| Trephine biopsy specimen surface area (mm 2 ) | 9.9 (8.4–11.5) | 7.1 (5.1–9.1) | 9.1 (7.2–10.9) | 0.047 |
| Bony trabecular surface area as percentage of trephine biopsy surface | 22.9 (19.6–26.1) | 25.6 (21.4–29.9) | 25.8 (21.8–29.8) | 0.40 |
| Trabecular width (μm) | 157 (140–175) | 166 (143–188) | 149 (127–171) | 0.56 |
| Bony trabeculae * | 16.1 (13.6–18.6) | 17.6 (14.3–21.0) | 19.8 (16.8–22.8) | 0.18 |
| Hemopoietic/leukemia cells * | 45.3 (39.6–50.9) | 21.5 (17.0–26.0) | 14.5 (11.6–17.5) | <0.0001 |
| Fat cells * # | 0.6 (0.3–1.1) | 2.4 (1.5–3.8) | 16.2 (11.7–22.3) | <0.0001 |
| Empty spaces * | 7.3 (5.6–8.9) | 13.9 (10.1–17.8) | 13.4 (10.3–16.5) | 0.0002 |
| Small vessels * | 0.5 (0.3–0.7) | 0.3 (0.04–0.5) | 0.4 (0.1–0.6) | 0.26 |
| Sinusoids * | 0.8 (0.2–1.4) | 1.7 (0.9–2.5) | 1.4 (0.8–2.1) | 0.15 |
| Sinusoid width (μm) | 32.5 (27.3–37.6) | 49.4 (43.2–55.7) | 46.7 (40.7–52.8) | 0.0001 |
| Extracellular matrix * | 25.7 (22.3–29.0) | 34.7 (30.4–38.9) | 23.7 (19.7–27.7) | <0.0001 |
| Red Cells * # | 1.6 (1.1–2.3) | 4.0 (2.6–5.9) | 3.2 (2.1–4.6) | 0.002 |
| Megakaryocytes** | 2.7 (1.4–4.0) | 5.5 (4.0–7.1) | 3.2 (1.72–4.73) | 0.013 |
| Reticulin fibres * | 17.6 (15.2–20.0) | 12.3 (9.0–15.6) | 7.9 (5.0–10.8) | <0.0001 |
| Osteoblasts *** # | 15.5 (12.7–19.0) | 14.6 (10.7–19.9) | 14.8 (12.5–17.6) | 0.89 |
| Osteoclasts**** | 1.6 (1.1–2.2) | 1.0 (0.7–1.6) | 1.2 (0.8–1.9) | 0.27 |
Mean values and 95% confidence intervals given.
* Percentage of crossing points occupied by element.
** Megakaryocytes were counted inside 20 whole squares of 0.02 mm2 each.
*** Osteoblasts were counted in 10 whole squares of 0.02 mm2 each.
**** Counted along all trabecular perimeters of the whole trephine biopsy specimen area.
# Geometric means (see Statistical Methods).