Fig 3. Signature of positive selection in highland populations, as revealed by various tests.

(A) F _ST between HL and LL. (B) Derived allele frequencies of HL. (C) Tajima’s D of HL. (D) Fay & Wu’s H of HL. (E) XP-CLR of HL against LL. (F) Absolute iHS score of HL. (G) CMSL score of HL. Black, green, and red dashed lines are 5%, 1%, and 0.1% thresholds respectively of each test in standard simulations. FAM213A gene and its enhancer, covered by the peak of the CMSL scores, are labeled in red.