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. 2015 May 11;10(5):e0126261. doi: 10.1371/journal.pone.0126261

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© 2015 Schreglmann et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Fig 2 — the number of BrdU-positive cells did not differ between transgenic a-Synuclein mThy1 and control animals (panel A). The analysis of the percentage of BrdU/TH-double-positive cells revealed a non-significant (p = 0.07) trend (panel B). The numbers of newly generated dopaminergic neurons are significantly reduced in the a-Synuclein transgenic animals (p = 0.04, panel C). Immunofluorescent confocal images of the glomerular cell layer show colocalization of markers of neuronal (NeuN, panel D) and dopaminergic differentiation (TH, panel E) with BrdU, a marker of cell survival (panel F). Scale bar 20μm.