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. 2014 Nov 11;25(4):469–480. doi: 10.1111/bpa.12190

Figure 4.

figure

Immunohistochemical characterization of TREM2 (triggering receptor expressed by myeloid cells 2) expressions in postmortem human brain tissues. Representative images of double immunohistochemistry of TREM2 (dark blue) and MHCII (major histocompatibility complex II) (brown) are shown in A–D; TREM2 immunoreactive microglia in association with neurons in E–F; TREM2 (dark blue) and p‐tau (brown) in G–I; and TREM2 and Aβ in J–N. A–D. TREM2‐immunoreactive microglia are present in MHCII‐negative (arrows) cells and also in MHCII‐positive cells (arrow heads). E–I. TREM2 immunoreactive microglia are in close contact with neuronal cell bodies (neutral red stained; E, F) in the tissues with minimal Alzheimer's disease (AD) pathology. Increased TREM2 immunoreactivity (dark blue, arrows) could be seen in the areas enriched with p‐tau immunoreactive neurites (brown; G–I). J–N. TREM2 immunoreactive microglia (dark blue, arrows; J–N) are observed in the vicinity of amyloid plaques (J–K) and inside amyloid plaques with different compactness of the amyloid aggregates (L–N). All of the micrograph images were taken with 40× objective. The 10‐μm magnification calibration bars were shown in the first picture in each row (A, E, G, J). The brain tissues for the morphological study were ND cases in A, B, E; PossAD cases in C, D, F, J, K; AD cases in G–I and L–N.