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. Author manuscript; available in PMC: 2016 May 7.
Published in final edited form as: Cell. 2015 Apr 30;161(4):868–878. doi: 10.1016/j.cell.2015.04.005

Figure 7. DNA methylation and histone methylation crosstalk.

Figure 7

A) Deletion of damt-1 suppresses the elevated H3K4me2 levels of late generation spr-5(by134) mutant worms. Each bar represents the mean ± SEM of 3 independent experiments performed in biological duplicate. Image J was used to analyze the relative intensity of H3K4me2 compared to Histone H3. Western blots corresponding to two of these experiments are shown in Figures S7A and S7B. B) Knockdown of H3K9me binding protein, eap-1, suppresses the elevated 6mA level detected in spr-5 mutant worms as assessed by dot blots. A longer exposure showing 6mA levels in WT worms is shown in Figure S7C.