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. Author manuscript; available in PMC: 2016 May 5.
Published in final edited form as: Cell Metab. 2015 May 5;21(5):777–789. doi: 10.1016/j.cmet.2015.04.009

Figure 4. KP372-1 induces NADH oxidation and impairs tumor growth in vivo without apparent toxicity.

Figure 4

(A and B) In vivo ratiometric fluorescence imaging of H1299 xenografts expressing SoNar (A) or cpYFP (B) in response to KP372-1. Images were pseudocolored with the ratio of fluorescence excited at 420 nm and 490 nm. Scale bar, 2 mm. (C) Quantification of the NAD+/NADH ratio in H1299 xenografts according to SoNar fluorescence. Error bars represent SD. (D) H1299 tumor-growth curves of untreated or KP372-1-treated mice. Error bars denote SEM (n=8 in each group). (E) Photographs of tumors after dissection at day 33. (F) H&E staining for the indicated tissues in animals treated with vehicle, 10 mg/kg KP372-1, or 20 mg/kg KP372-1 daily for 33 days. See also Figure S4 and Table S3.