Inverse log10 transformed P-values for crude associations of 257 independent SNPs between 34 and 36 Mb on chromosome 17 with wheezing phenotypes (compared with never/infrequent wheeze). Vertical red lines delineate region between 35.2 and 35.4 Mb around ORMDL3 (marked in green) containing 13 asthma-related SNPs 5, 22, 23 (highlighted in red). Grey gene tracks show loci in the order PNMT, PERLD1, ERBB2, C17orf37, GRB7, IKZF3, ZPBP2, GSDML, GSDM1, PSMD3, CSF3, MED24.