Table 1.
Characteristics of children included in analyses
| Number of children with data available | Number (%) of children with characteristica | Sub-sample with expression data (n=947) | Number (%) with characteristic in subsamplea | |
|---|---|---|---|---|
| Male sex | 7045 | 3595 (51.0) | 875 | 413 (47.2) |
| Maternal history of asthma or allergy | 6723 | 3140 (46.7) | 855 | 423 (49.5) |
| Paternal history of asthma or allergy | 4963 | 1994 (40.2) | 671 | 267 (39.8) |
| Prenatal maternal smoking | 6786 | 1516 (22.3) | 857 | 136 (15.9) |
| Maternal lower education levelb | 6853 | 4012 (58.5) | 864 | 445 (51.5) |
| Wheezing phenotypec | 7045 | 947 | ||
| Never/Infrequent | 4815 (68.4) | 682 (72.0) | ||
| Transient Early | 715 (10.2) | 81 (8.6) | ||
| Prolonged Early | 526 (7.5) | 58 (6.1) | ||
| Intermediate Onset | 162 (2.3) | 20 (2.1) | ||
| Late Onset | 335 (4.8) | 48 (5.1) | ||
| Persistent | 492 (7.0) | 58 (6.1) | ||
| Doctor-diagnosed asthma ever by 7½ years | 5497 | 1085 (19.7) | 815 | 149 (18.3) |
| Skin prick test sensitivity at 7.5 years | 4710 | 948 (20.1) | 728 | 123 (16.9) |
| Mean [IQR] FVCd at 8.5 years (l) | 4831 | 0.02 [1.26] | 833 | 0.03 [1.23] |
| Mean [IQR] FEV1d at 8.5 years (l) | 4758 | 0.02 [1.29] | 821 | 0.04 [1.20] |
| Mean [IQR] FEF25_75d at 8.5 years (l/s) | 4831 | 0.02 [1.33] | 833 | 0.02 [1.21] |
| BHRd at 8.5 years | 3216 | 875 | ||
| No BHR (LSDRS<0) | 616 (19.2) | 93 (15.5) | ||
| Positive BHR (1st tertile) | 869 (27.0) | 152 (25.3) | ||
| Positive BHR (2nd tertile) | 867 (27.0) | 184 (30.7) | ||
| Positive BHR (3rd tertile) | 864 (27.0) | 171 (28.5) |
a
Unless labeled as Mean [IQR]
b
Educated to GCE level (school leaving certificate) or lower
c
Estimated using posterior probabilities
d
FVC= forced vital capacity (adjusted z-scores), FEV1= forced expiratory volume in 1 s (adjusted z-scores), FEF25_75= forced 6 expiratory flow 25–75% (adjusted z-scores), BHR=bronchial hyper-responsiveness, LSDRS=least square dose response slope