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. Author manuscript; available in PMC: 2015 May 12.
Published in final edited form as: J Allergy Clin Immunol. 2012 Nov 13;131(3):685–694. doi: 10.1016/j.jaci.2012.09.021

Table 2.

Association of variants in the region of chromosome 17 between 35.0 and 35.5 Mb (around 17q21) with wheezing phenotypes in 7,045 children

Nearby gene a SNP b Position (Mb) MAF c Overall P-value Ph d Risk allele± RRR (95%CI) e P-value for Ph Other SNPs (overall p-value) f
Region between 35.0 and 35.2 Mb g
PNMT rs876493 35.078071 0.41 0.002 TE A (common) 1.02 (0.91, 1.14) 0.79 NA
PE G 1.10 (0.97, 1.25) 0.13
IO G 1.35 (1.06, 1.73) 0.02
LO G 1.08 (0.93, 1.26) 0.33
P G 1.29 (1.11, 1.48) 6.52×10−4
PERLD1 rs2941504 35.084426 0.31 0.001 TE G (common) 1.01 (0.91, 1.13) 0.81 NA
PE A 1.06 (0.94, 1.20) 0.36
IO A 1.27 (1.00, 1.60) 0.05
LO A 1.10 (0.95, 1.28) 0.21
P A 1.31 (1.14, 1.51) 9.98×10−5
ERBB2 rs2952155 35.229995 0.24 0.004 TE C (common) 1.03 (0.91, 1.16) 0.64 No signals
PE T 1.06 (0.93, 1.22) 0.39
IO T 1.29 (1.00, 1.67) 0.05
LO T 1.10 (0.93, 1.29) 0.27
P T 1.31 (1.13, 1.53) 3.68×10−4
Region between 35.2 and 35.4 Mb
IKZF3 rs9303277 35.229995 0.48 2.24×10−11 TE T (common) 1.02 (0.92, 1.12) 0.77 rs9635726 (0.004)
PE C 1.14 (1.02, 1.28) 0.024
IO C 1.52 (1.21, 1.91) 2.81×10−4
LO C 1.15 (1.00, 1.32) 0.05
P C 1.57 (1.37, 1.79) 4.43×10−11
ZPBP2 rs11557467 35.282160 0.48 3.52×10−11 TE T (common) 1.02 (0.92, 1.13) 0.73 rs8067378 (6.37×10−11)
PE G 1.14 (1.02, 1.28) 0.02 rs12150079 (3.57×10−6)
IO G 1.50 (1.20, 1.89) 4.11×10−4
LO G 1.16 (1.01, 1.33) 0.04
P G 1.56 (1.37, 1.78) 5.99×10−11
GSDML rs2305480 35.323475 0.48 1.69×10−12 TE T (common) 1.03 (0.93, 1.15) 0.51 rs7216389 (4.82×10-12)
PE T (common) 1.17 (1.05, 1.31) 0.006 rs2290400 (6.66×10-12)
IO T (common) 1.58 (1.25, 1.99) 1.11×10−4
LO T (common) 1.16 (1.01, 1.34) 0.03
P T (common) 1.60 (1.39, 1.83) 1.5×10−11
Region between 35.2 and 35.4 Mb
ORMDL rs8076131 35.334438 0.48 8.55×10−13 TE A (common) 1.05 (0.95, 1.17) 0.31 rs4795405 (3.08×10−12)
PE A (common) 1.18 (1.06, 1.33) 0.004 rs4378650 (6.76×10−12)
IO A (common) 1.60 (1.27, 2.02) 7.52×10−5 rs4794820 (7.04×10−12)
LO A (common) 1.19 (1.03, 1.37) 0.02 rs8079416 (1.06×10−8)
P A (common) 1.60 (1.40, 1.84) 1.41×10−11 rs3744246 (5.57×10−4)
GSDM1 rs3902025 35.372780 0.44 1.20×10−9 TE T (common) 1.09 (0.98, 1.20) 0.12 rs4795408 (1.38×10−8)
PE T (common) 1.17 (1.04, 1.31) 0.009 rs3859192 (2.23×10−8)
IO T (common) 1.46 (1.16, 1.85) 0.001 rs7219080 (5.34×10−8)
LO T (common) 1.15 (1.00, 1.33) 0.05 rs3894194 (6.36×10−8)
P T (common) 1.53 (1.33, 1.75) 1.46×10−9
Region between 35.4 and 35.5 Mb
PSMD3 rs2227321 35.424820 0.37 1.60×10−6 TE G (common) 1.00 (0.90, 1.11) 0.95 rs8075668 (6.80×10−6)
PE G (common) 1.14 (1.01, 1.28) 0.04 rs2241245 (0.003)
IO G (common) 1.38 (1.09, 1.76) 0.009
LO G (common) 1.17 (1.01, 1.35) 0.04
P G (common) 1.42 (1.23, 1.64) 1.36×10−6
CSF3 rs1042658 35.427428 0.38 3.45×10−5 TE T 1.05 (0.95, 1.16) 0.36 NA
PE T 1.12 (1.00, 1.26) 0.05
IO T 1.36 (1.08, 1.70) 0.008
LO T 1.15 (1.00, 1.32) 0.05
P T 1.34 (1.18, 1.53) 1.13×10−5
MED24 rs8065443 35.462466 0.41 5.84×10−6 TE A 1.07 (0.96, 1.18) 0.22 rs2302776 (1.77×10−4)
PE A 1.18 (1.05, 1.32) 0.006
IO A 1.31 (1.05, 1.65) 0.02
LO A 1.17 (1.02, 1.35) 0.03
P A 1.36 (1.2, 1.56) 4.15×10−6
a

From online database SNP Function Prediction (FuncPred): http://manticore.niehs.nih.gov/snpfunc.htm

b

SNP with the smallest overall p-value, only for genes for which there is evidence of association for at least one variant (p<0.001). A complete list of results for all SNPs is available from the authors on request. SNPs highlighted in bold are the 13 previously reported asthma-related SNPs5 22 23.

c

MAF=Minor allele frequency, RRR=Relative risk ratio

d

Ph= Phenotype: TE=Transient early, PE=Prolonged early, IO=Intermediate onset, LO=Late onset, P=Persistent

e

Risk allele is rare allele unless indicated otherwise

f

Overall p-values for other SNPs within the same gene which are also associated with intermediate onset and persistent wheezing only.