Fig. 7.

Differential phenotypes for L66 (a, b) and L1 (c, d) on the balance beam and in the light/dark box tests (e, f). For heterozygous L66 mice (6–7 months), while performing equally or better than age-matched controls at 5- or 12-mm beams, deficiencies were observed in homozygous females, which were impeded at all beams (a, b). Note that animals with dyskinesia performed worse than normal age-matched homozygous mice (WT n = 24; L66^+/− n = 14, L66^+/+ n = 25). For 5- to 6-month-old L1 mice, latency to traverse square beams was shorter (better performance) than wild type (n = 14 each, females) (c). There was a similar finding for L1 with round beams (d). Increase in latency for the more difficult beams reflects the more challenging nature of small beams. In the light/dark box test, L1 and control mice aged 7–8 months (WT n = 13; L1 n = 13) spent similar amounts of time in the dark compartment (e) and presented with comparable number of entries (f). Values expressed as mean + SE; asterisks denote group differences (Student’s t test) at p < 0.05. ^{^}Statistically significant difference from all the other groups; ^$difference from WT and L66^+/− groups