Table 1.
Baseline Characteristics of CRT Responders and Nonresponders
| ALL (n=75) | RESPONDER (n=40) | NONRESPONDER (n=35) | p-value | |
|---|---|---|---|---|
| Demographic/Clinical* | ||||
| Age, years | 65.9 (57.8–74.3) | 65.3 (57.7–72.6) | 67.9 (59.2–76.4) | 0.35 |
| Female Gender | 19 (25.3) | 16 (40.0) | 3 (8.6) | 0.003 |
| NYHA Class II/III/IV | 3/71/1 (4.0/94.7/1.3) | 3/37/0 (7.5/92.5/0) | 0/34/1 (0/97.1/2.9) | 0.17 |
|
| ||||
| CMR imaging parameters* | ||||
| LVEF, % | 23.2 (15.0–28.4) | 22.8 (16.1–27.9) | 23.2 (13.8–28.4) | 0.81 |
| LVEDV index, ml | 122 (104.1–151.0) | 110.0 (91.4–139.3) | 133.7 (110.5–155.6) | 0.007 |
| LVESV index, ml | 96.9 (78.0–126.4) | 88.0 (71.6–116.1) | 109.3 (86.8–136.6) | 0.02 |
| SV index, ml | 26.8 (21.2–33.9) | 26.1 (21.0–28.0) | 31.0 (24.0–38.0) | 0.03 |
| LV mass index, g/m2 | 70.9 (59.4–82.9) | 63.6 (49.5–80.7) | 74.6 (66.0–90.2) | 0.006 |
| LGE present | 41 (54.7) | 17 (42.5) | 24 (68.6) | 0.04 |
| LV per. scar volume (%) | 4.3 (0–12.7) | 0 (0–12.3) | 7.3 (0–12.9) | 0.12 |
| CURE | 0.61 (0.36–0.74) | 0.37 (0.26–0.61) | 0.75 (0.64–0.81) | <0.0001 |
|
| ||||
| Electrical activation and scar at LV lead* | ||||
| QLV | 108 (72–140) | 125 (107–143) | 90 (60–105) | 0.0002 |
| Lead position in scar | 28 (37.3) | 8 (20.0) | 20 (57.1) | 0.002 |
| Initial mechanical stretch | 43 (57.3) | 29 (72.5) | 14 (40) | 0.006 |
|
| ||||
| ECG parameters* | ||||
| QRS Duration, ms | 155 (140–170) | 160 (150–172) | 150 (134–170) | 0.12 |
| LBBB | 67 (89.3) | 39 (97.5) | 28 (80.0) | 0.02 |
|
| ||||
| Comorbid conditions* | ||||
| Prior MI | 34 (45.3) | 14 (35.0) | 20 (57.1) | 0.06 |
| Prior CABG | 9 (12.0) | 4 (10.0) | 5 (14.3) | 0.72 |
| Chronic kidney disease | 15 (20.0) | 10 (25.0) | 5 (14.3) | 0.38 |
| Diabetes mellitus | 21 (28.0) | 9 (22.5) | 11 (34.3) | 0.30 |
| Peripheral art. disease | 9 (12.0) | 3 (7.5) | 6 (17.1) | 0.28 |
| Hypertension | 41 (54.7) | 24 (60.0) | 17 (48.6) | 0.36 |
| Prior stroke/TIA | 7 (9.3) | 5 (12.5) | 2 (5.7) | 0.43 |
| Obstructive Sleep Apnea | 15 (20.0) | 7 (17.5) | 8 (22.9) | 0.58 |
|
| ||||
| Events during follow-up* | ||||
| Death | 16 (21.3) | 2 (5.0) | 14 (40.0) | 0.0004 |
| Sustained VT | 12 (16.0) | 2 (5.0) | 10 (28.6) | 0.01 |
| HF hospitalization | 20 (26.7) | 3 (7.5) | 17 (48.6) | <0.0001 |
*
Values are median (IQR) for continuous variables and number (%) for categorical variable.
The numbers in parentheses for NYHA class are the percentages of patients in each class.